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In both cases the intervention was terminated and the adverse effects stabilised immediately.
In both cases, the intervention is applied to those aged 55 years and above, an age group considered to be at higher cardiovascular risk.
In both cases, the intervention group respondents improved in correctly answering clinical decision questions that involved applying prognosis information, reaching statistical significance in one of two cases (9/18 to 17/18, p = 0.005) but inter-group difference was not significant at follow-up (p = 0.07).
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In contrast, if the latter hypothesis is correct, LVHN's experience demonstrates how CDS can be used to correct an unintended consequence of CPOE.In both cases the CDS intervention led to a positive outcome, but the two underlying reasons for the over-use error have very different implications for the efficacy of CPOE.
In both these cases, the intervention is designed to redirect pre-mRNA processing, in the case of DMD, through induction of targeted exon skipping, while in SMA, the aim is to promote exon retention to produce a functional transcript.
In both cases, the reduction observed after the intervention was not significant, nor was the difference in differences.
In both cases, the use of an intervention specific to the workplace (on-site work evaluations and graded work exposure) was successful in promoting return to work (88%and87%7% reported in each study).
Although quality improvement activities share some of the characteristics of clinical research and the boundary between these two areas often overlap (in both cases the effectiveness of an intervention is measured) there are, nonetheless, fundamental differences between the two areas that justify the adoption of different procedures for guaranteeing ethical conduct.
For example, only two studies [ 17, 42] looked at anti-smoking interventions and in both cases these interventions were not the main focus of the analysis.
In both cases we are dealing with possibly life-threatening situations, and in both cases the effects of an extraordinary intervention might solve the problem.
In many cases, the intervention is realized using composite materials bonded to the surface of the structural element.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com