Magnetic resonance images from both case and control populations were manually segmented to determine LAA volume.
Both case and control serum samples were collected from four study centers.
Firstly, we randomly drew samples from both case and control groups.
Phenotypes for anthropometric and biochemical traits related to glucose metabolism were extensively measured for both case and control subjects.
SNPs with minor allele frequency of ≤0.1 in both case and control samples were excluded from the further analysis.
The deletion/deletion (DD) haplotype was the most frequent haplotype in both case and control populations, with a significantly higher frequency in the cases than controls (p = 0.032).
After constructing CNVRs from identified CNVs, the number of CNVs in the regions were counted in both case and control groups.
SNPs with minor allele frequency (MAF) of <0.01 in both case and control samples were excluded from the further analysis (Table S2).
For both case and control mice, lethal comas were induced by injecting mice i.p. with a 0.6 0.8 mL 5% Avertin (2,2,2-Tribromoethanol, Sigma).
Again, the comparison would be fairer if the additional 9 variants, that were present in both case and control groups, had been included for analysis.
When the sample sizes of both case and control are equal to two, SWang(1,2) or SWang(1,1) should be adopted in the DEGs selection process.
