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Both bone overload and excessive stress protection can result in bone resorption.
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Therefore, one is not interchangeable by the other, as illustrated by the study of Buck et al. showing that uptake on scintigraphy is more sensitive compared to bone marrow edema on MRI to detect mechanical bone overload in patients with chronic medial knee pain (Fig. 4a) (Buck et al. 2009).
Orthopaedic and dental implant fixation depends on both bone and bone implant contact, and bone formation around implant.
In contrast, bone "overloading" would induce rapid regional bone activation and remodeling but also increase the density of microdamages.
Micro-computed tomography (micro-CT) is a nondestructive method for assessing both bone quantity and bone quality.
It is then screwed into place with a torque controlled drill at a precise torque so as not to overload the surrounding bone (overloaded bone can die, a condition called osteonecrosis, which may lead to failure of the implant to fully integrate or bond with the jawbone).
Osteoporosis is a bone disease that can reduce both bone mass and bone strength.
Both Ca2+ overload and depletion of the ER Ca2+ pool can result in changes in protein folding and ER stress.
Both metal overload and deficiencies can cause metabolic defects, cell cycle arrest and cell death leading to severe pathologies [ 1- 4].
Patients with more severe endothelial dysfunction tend to develop both fluid overload and AKI following fluid administration.
A progressive exercise program sustains overload and the bone adaptation process.
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