Sentence examples for both binding sites of from inspiring English sources

HINT analyses indicate favorable multi-point interactions of the activators in both binding sites of the two forms of antithrombin.

The crystal structuresdemonstrate that, in accord with the previously reported bisubstrate character of ARCs, the inhibitors occupy both binding sites of PKAc.

It is worth noting that the current motif analysis, including both binding sites of STAT1 and its collaborating factors, relies on the position specific scoring matrix (PSSM) in the TRANSFAC database [28].

The fact that the crystal structure of an AgamOBP1 dimer has been determined in the presence of the very long PEG molecule occupying both binding sites of the monomers through a polar dimer interface may indicate the ability of the ligand binding pocket to accommodate various sizes and types of ligands.

For E3 and E5, however, mutations in either a single or both binding sites of each reporter completely abolished expression in the PMZ.

In whole embryos, mutations in either of the Pitx-binding sites or in both binding sites of E1 still showed GFP expression without selectivity, in the middle of the embryo.

Through a combined use of rationally designed mutations of the Josephin domain and a detailed comparison of the enzymatic properties of the domain with those of full-length ataxin-3, we confirm that, in the absence of other competitors, Ub chains are able to bind both Ub binding sites of Josephin.

Additionally, although each individual deletion resulted only in a weak repression of luciferase activity, deletion of both binding sites abolished miR-491-5p-induced miR-491-5p-induced miR-491-5p-induced miR-491-5p-induced

All TTR∶ligand complexes were prepared from crystals soaked with a fivefold molar excess of ligand for 3 4 weeks to ensure saturation of both binding sites without affecting the diffraction quality of the crystals.

Inactivation of both binding sites abolishes the anti-invasive activity of M6P/IGF2R, which suggests that M6P-modified ligands of the receptor play a key role in the migration of SCCs cells across basement membranes.

Hence, the co-occurrence of both binding sites is apparently not a prominent feature of imprinted gene regulation.