Sentence examples for both binding pockets of from inspiring English sources

Hence, we can expect that in the trimeric Pol III clamp exonuclease complex, both binding pockets of the clamp are occupied, one by the internal clamp binding motif of Pol III and one by the exonuclease clamp binding motif.

With both binding pockets of the clamp occupied by Pol III and the exonuclease, as well as additional interactions of the Pol III tail with the clamp, most of the clamp is protected in the trimeric Pol III clamp exonuclease complex.

In pulldown experiments using recombinant Impα3 derivatives, effective interaction with the MRTF-A extended NLS was dependent on the integrity of both binding pockets, and increased upon removal of the N-terminal Impα IBB domain.

The overall molecular structure of the TTR∶inhibitor complexes are very similar to that of native TTR. Figure 2a shows the binding of 15 to both hormone binding pockets of the TTR tetramer.

The bivalent inhibitor possesses a lysine-head and an arginine-head, both occupying the substrate binding pockets of two different NS3Pro molecules simultaneously (Murthy et al., 2000).

(6) Small molecules are synthesized to specifically bind to RNA binding pockets of lncRNAs.

Additionally, structural interaction fingerprints analysis identified the important amino acid residues for the specific interactions of long-chain arylpiperazines within the binding pockets of both serotonin receptors.

To understand the species selectivity in a series of α-methyl-α-phenoxy carboxylic acid PPARα/γ dual agonists (1 11), structure-based molecular modeling was carried out in the ligand binding pockets of both human and mouse PPARα.

The fused bifunctional enzyme therefore represents an excellent vehicle for finding inhibitors that engage the pterin binding pockets of both modules that have entirely different architectures.

The fluorenyl moiety is sandwiched between the hydrophobic groups of residues Lys15, Lys15', Leu17, Leu17', Thr106, Thr106', Ala108, Ala108', Val121 and Val121' in the outer binding pockets of both AC and BD dimer.

On the basis of the results obtained in docking simulations as described in the Materials and methods section, we evaluated the affinity of MIBE for the ligand binding pockets of both ERα and GPER with respect to E2 and G-1, respectively.