Sentence examples for both binding and viral from inspiring English sources

Furthermore, in patch 2, a single-residue substitution of either L506A or W553A, expected to alter the hydrophobic core, significantly reduced both binding and viral entry efficiency.

Finally, a single-residue substitution of D510A that disrupts its salt-bridge interaction with DPP4 R317, or a change of E513A that disrupts its hydrogen-bonding interaction with DPP4 Q344, also hindered, to variable degrees, both binding and viral entry; while the impact of other mutations such as R511A was not significant.

Hemagglutinin is responsible for both receptor binding and viral fusion to host cells.

We also noticed other polymorphisms in the CypA binding loop at positions 218 and 222 that may have unknown effect on CypA binding and viral replication.

L4 is essential for membrane binding and viral resistance by direct interaction [ 46, 47].

Collectively, this information points to alternate binding and viral inhibition modes of these two mAbs.

NTCP residues 157 to 165 were identified to be critical for pre-S1 binding and viral infections.

10.7554/eLife.00049.023 Figure 7. Identification of a critical region (aa 157 165) of NTCP for pre-S1 binding and viral infections.

Similarly, combined substitutions involving E536R, D537K and D539K, hypothesized to disrupt the native interaction with K267, resulted in profound reduction in the binding and viral entry levels.

For example, E3L protein of vaccinia virus (VACV) [19] or the TRS1 protein of cytomegalovirus [20] inhibit the activation of PKR by binding and sequestering viral dsRNA.

There exists a theoretical possibility, therefore, that membrane-bound blood group substances on CD4-positive cells may thus affect the affinity of viral-binding proteins and viral infectivity, promoting or diminishing cell susceptibility to infection.