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These files contained all known interactors — both binary and co-complex — for the query protein, the experimental method used to detect the interaction and the publication reference.
We applied our framework to both binary and co-complex gold-standard PPI data sets.
We find that the average degree for both S. pombe and O. sativa are much lower than that of human or S. cerevisiae for both binary and co-complex data.
Similar(57)
It establishes and implements systematic techniques for separating interactions based on both type (i.e., binary and co-complex) and data-source (i.e., LC and HT).
HINT clearly distinguishes between binary and co-complex interactions.
The AUC of binary and co-complex PPI data sets are 0.958 and 0.999.
For batch download, separate links are provided for binary and co-complex interactomes for each organism.
High-quality binary and co-complex human protein interactome networks were obtained from HINT [ 16].
Our interactome comprises a total of 42,604 binary and co-complex interactions among 9,985 proteins.
Hence the whole interactome is HT. Figure 2 depicts the binary and co-complex interactomes for human and S. cerevisiae.
For binary and co-complex data sets, the performance of KEGG-based similarity shows no big difference.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com