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Both batch and fed-batch experimental observations are simultaneously employed to formulate the parameter estimation problem.
The validated kinetic model could fit for both batch and fed-batch fermentation processes as observed from the experimental results.
It was therefore used to model both batch and fed-batch fermentation results where growth inhibition caused by induction was pronounced.
There were significant differences (P < 0.05) in maximum viable cell concentration, viable cell yield, viable cell productivity, lactic acid production, yield and productivity obtained for both batch and fed-batch fermentations.
Our results showed that inhibition of either endogenous caspase-8 or caspase-9 enhanced the viability of the CHO cells in both batch and fed-batch suspension cultures, but the inhibition of caspase-2 had minimal effects.
Prefermentation enhances xylose uptake most likely because of the reduced transport inhibition, in both batch and fed-batch operation.
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(Shah et al. 2007) studied sophorolipid production by C. bombicola in both batch and fed batch fermentations.
This agrees with the experimental evidence: even if glycerol is typically considered a non-fermentable carbon source in P. pastoris, residual ethanol production has been reported both in batch and fed-batch cultures [ 41, 42].
Remarkable improvements on acarbose titer, acarbose productivity, and proportion of acarbose/impurity C were successfully achieved when 20 mg/L of validamine was added in the fermentation medium prior to inoculation both in batch and fed-batch cultures.
In both the batch and fed-batch cultivations growth was similar to that of the parental strain and peak expression of ZERA-GLA was achieved at the end of the cultivations when CO2 levels had decreased almost to the baseline after exhaustion of carbon source.
The reactions in batch and fed-batch reactors are discussed.
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