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Following Hughes [35], evidence of both balancing selection and recombination between exon 2 and intron 1 in each species was evaluated by comparing mean genetic distance (d) among intron 1 alleles and mean synonymous genetic distance (dS) at functional exon 2 alleles within functional clades defined using putative ABS identified by the method outlined above.
Inbreeding coefficients showed evidence of both balancing selection and genetic drift acting on immune-linked loci in SMMNRA.
Deep haplotype genealogies might result from both balancing selection and ancient population structure (reviewed in [ 62]).
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We found evidence of selective sweeps, balancing selection, and positive selection affecting both protein-coding and noncoding DNA of pathogenicity-related sequences.
An ω value greater than 1 supports directional or balancing selection, and less than 1 supports purifying selection [ 30].
Since we detected strong signals of both positive and balancing selection within the same region for different human and non-human primate populations, chance and demographic history alone can not fully explain our observations.
In Europeans, the evidence is more complex, and both directional and balancing selection may be involved in light skin.
This makes the test for balancing selection conservative, and it is possible that the modest positive TjD values here for sera5, Pf38/6-cys, and msp7 also reflect balancing selection.
The current study found that regions of the genome under purifying and balancing selection through both domestication and improvement were enriched for NBS-encoding genes.
Sequence level studies have shown that while female reproductive genes can show evidence of evolutionary pressure, the type and strength of selection is more variable than typically found in males, i.e. both positive and balancing selection [ 8, 10].
Specifically, there is an unexpected high number of acute phase proteins showing signatures of balancing selection, both in Africans and Europeans (Fisher's exact test P = 0.03 and 0.008, respectively).
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