Sentence examples for both at the systemic from inspiring English sources

Rheumatoid arthritis (RA) is a chronic inflammatory disease, which results from a complex interplay of factors both at the systemic level and at the site of inflammation [ 1].

Furthermore, animals which were able to maintain flow, both at the systemic and microcirculatory level, had more timely reversal of the shock state during resuscitation.

We could not find differences in the effects that a session of NMES with medium and high frequencies has on skeletal muscle microcirculatory function, both at the systemic and local level.

This Th2 cytokine polarization occurs both at the systemic level and at the fetal-maternal interface [ 9].

Taken together, all the immunological parameters tested suggest that MSCs induced a switch of the immune response towards a Th2 cytokine production profile both at the local and systemic level.

Thus, not only TC-PTP+/− mice are more sensitive to DSS-induced colitis, but they also respond more severely to DSS-treatment both at the local and systemic levels.

Even though Django ultimately escaped castration, the scene was a reminder of the literal and metaphorical emasculation of black men that has gone on, at both the systemic and individual levels, in America since before the states got their independence from England.

Circadian genes have been shown to function as oncogenes or tumor suppressors at both the systemic and cellular levels due to their roles in cell proliferation, cell cycle regulation, apoptosis and DNA damage signaling pathways [8], [9].

Emerging evidence indicates that the hypoxia-inducible factor (HIF) family of transcription factors plays a central regulatory role in these homeostatic changes at both the systemic and cellular levels.

The biological effects of this treatment have been evaluated at both the systemic [ 6, 7] and synovial [ 8- 10] levels, although it remains unclear how each of these contributes to the overall clinical responses in the treated patients as measured using indices such as the DAS.

ZOL treatment decreases the serum levels of both these markers (Figure 2) indicating that ZOL has inhibited both osteoclast and osteoblast activity at the systemic level.