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Our study might also suggest that pERK could represent a mark of previously activated synapses, both at the pre- and at the post-synaptic level.
It appears that A βo acts as a nonspecific pathological receptor ligand/agonist, both at the pre- and postsynaptic membrane.
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These interventions have been tested for their efficacy in case of SCI both at the pre-clinical and clinical level.
Single-photon emission computed tomography (SPECT) provides a valuable tool for dopamine neurotransmission visualization both at the pre-synaptic and post-synaptic levels by means of several tracers [7, 8].
MicroRNA-34a regulates SIRT1 expression both at the pre-transcriptional level, by regulating expression of transcription factor SP1 [ 16], and also at the post-transcriptional level, by binding to the 3' untranslated region (UTR) of SIRT1 transcript [ 28] to repress its expression.
We found that MPA treatment decreases DNAse I sensitivity, consistent with a less accessible and repressive chromatin environment both at the potential PRE and at the TSS regions.
arabiensis is expressed both at the pre-zygotic and post-zygotic level.
Firstly, syllable stress might be tightly linked to phonemes both at the pre-lexical level and at the lexical level of representation.
Patients with Parkinson's disease show impairment both at the level of pre-attentional visual processing (Lieb et al., 1999), and later at the level of saccade execution.
The prescription of first-line anxiolytics and antidepressants were not statistically different between groups at baseline, whereas the prescription of antipsychotics and hypnotics/sedatives were significantly lower for the AIC cohort both at the 90 and 180 days pre-index visit periods (Table 2).
Eph and ephrin expressions are not restricted to synapses: they are found at both the pre- and post-synaptic membranes, and also, at least some isoforms, on astrocytes (Klein, 2009).
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