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Biological information resources –both at the functional and molecular levels– may be either unstructured (large scale experimental data repositories, research papers and paper-collections as well as in-process annotations) or structured at different levels, from curated annotations and systematized repositories to quite specific and highly-curated knowledge-based resources.
Accordingly, our results combining Sorafenib and Casodex successfully overcame the PTEC resistance to Sorafenib both at the functional level and on the Akt pathway activation.
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We conclude that an appreciation of overlap both at the functional-level and at the design aspects-level allows simpler yet comprehensive implementations of RFID middlewares.
The efficacy of the tankyrase inhibitor JW74 was evaluated in three OS cell lines (KPD, U2OS, and SaOS-2) both at the molecular and functional level.
Thus, characterization of the interaction between receptors and environmental compounds both at the structural and functional levels, as well as the development of robust in vivo, in vitro, and in silico screening methods, are important for the assessment of the global hormonal activity of a large number of chemicals (Janosek et al. 2006).
At the same time, both the functional "driver" mutations and the associated "passenger" mutations occur rarely; therefore, it is nearly impossible to distinguish them solely based on the frequency of individual genes [ 7, 8].
Establishing a modular map of regulatory elements within the upstream regions of each gene locus as part of reference genome annotations in a similar manner that we understand protein domain architectures of coding sequences will be an important tool for various applications in comparative functional genomics both at the intraspecific and interspecific levels.
This article reviews the application of PET in angiogenesis imaging at both the functional and molecular level.
We evaluated common and unique aspects at both the functional (Gene Ontology) and gene level of MeHg-induced response.
Our methodology uses the same power modeling approach for the MPSoC at both the functional and transactional levels in order to guarantee the coherence of the estimation strategy.
Individual variation in the susceptibility of the auditory system to acoustic overstimulation has been well-documented at both the functional and structural levels.
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