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It would be of interest how APOA1 rs670 and HDL-C interact with ER polymorphisms both at a systemic and local (mammary tissue) level in these patients.
This temporal variation in disease pathology is directed by the circadian clock, both at a systemic level, through signalling pathways derived in the central clock, and at a local level by autonomous clocks found within inflammatory organs and cells.
This control is exerted both at a systemic level, through signalling pathways originating in the central clock, and at the local level by autonomous clocks in inflammatory cells and tissues.
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Rheumatoid arthritis (RA) is a chronic inflammatory disease, which results from a complex interplay of factors both at the systemic level and at the site of inflammation [ 1].
Inefficiency exists at a systemic level as well.
If you consider this at a systemic level, shooting always makes sense in a moment of indecision.
The benefits may be great for some, but the challenges will be enormous at a systemic level.
"As a black woman, I am very limited in what I can do, quite frankly, at a systemic level," Moore-Roberts said.
Once this is established how do we measure quality in a program and at a systemic level?
Addressing this inequality is itself a wicked problem that will require multiple avenues to address at a systemic level.
The court mandated that the Legislature was to enact "broad and sweeping reforms at a systemic level, statewide".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com