Sentence examples for both as single agents from inspiring English sources
These inhibitors have demonstrated efficacy both as single agents and in combination therapy to improve patient outcome.
A number of groups have investigated other, newer drugs in advanced pancreatic cancer both as single agents and in combination.
12 Doxorubicin and ifosfamide have been used both as single agents and as combination therapy and remains the mainstay of treatment in most histologies of STS.
The approved taxanes, paclitaxel and docetaxel, have a broad spectrum of antitumour activity both as single agents and in combination, and are widely used for cancer treatment (Choy, 2001).
For this purpose, 5-FU or new compounds direct thymidylate synthase (TS) inhibitors like raltitrexed and nolatrexed, or irinotecan (CPT-11) and oxaliplatin, have established activity both as single agents and in combination.
To date, clinical trials have focused mostly on hematopoietic cancers whereas application of these drugs in solid tumors both as single agents and as cotherapeutics is an emerging strategy.
Recombinant TRAIL (dulanermin) and several monoclonal antibodies targeting DR5 are in clinical trials both as single agent and in combination therapies.
Gemcitabine has shown a high antitumor activity in the treatment of MBC both as single agent and in association with other cytotoxic drugs [ 10, 11].
Recently, several prospective and retrospective studies provided clinical data on bevacizumab activity both as single agent and in combination therapy, establishing this antiangiogenetic agent as a valuable and active treatment option in rMGs.
Recently, several prospective and retrospective studies provided clinical data on BEV activity both as single agent and in combination therapy, establishing this antiangiogenetic agent as a valuable and active treatment option in GBM [ 12– 12].
Although no prospective and randomized studies were performed about the efficacy of fotemustine in malignant gliomas, results from numerous retrospective and prospective single-arm phase II clinical trials demonstrated its activity both as single agent and in combination with other cytotoxic drugs or new targeted drugs such as bevacizumab.
