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Based on up-to-date knowledge of immune evasion and rational considerations, the model is designed to illustrate how tumors evade both arms of host immunity (i.e. innate and adaptive immunity).
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As they do so, they activate two critical arms of host defense, the rapid innate immune response and an adaptive immune response.
Our results underscore the fundamental importance of both cellular and humoral mechanisms in Drosophila immunity and shed light on the balance between these two arms of host defense depending on the invading pathogen.
The host innate immune system is the major barrier for pathogens to succeed in infection, and the complement system is one of the main arms of host defense [9].
Innate and adaptive immune responses are the two main arms of host immune system to combat invading pathogens.
To better understand the interactions between these two arms of host immunity, we studied two canonical pathways: 1) communication between DC and NK cells at 2 weeks and 2) interaction between innate and adaptive immune cells at 4 weeks post-infection.
Both arms of Congress held hearings.
Animals in both arms of the study were euthanized.
In both mice and Toll pathway mutant flies, the cellular arm of host defense plays a paramount role.
Several recent studies performed with more pathogenic bacteria suggest that the cellular arm of host defense plays a more important role in the response against some of these infections [17], [18], [19].
It is conceivable that targeting 3 antigens simultaneously provided neutralization of antigens important for suppressing several arms of the host defense (in this case, host coagulation and complement) and resulted in impaired tick feeding.
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CEO of Professional Science Editing for Scientists @ prosciediting.com