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Preferential release from the front head implies that the kinetics of the two heads are differentially affected when both are bound to the microtubule, presumably by internal strain that is responsible for the gating.
Don't get me wrong, both are bound to IPO at some point, and they'll be high-profile and plenty impactful events.
Due to the workload from competing sources, it is not possible for the driver to respond in an optimum manner to the primary task (driving) and secondary task (e.g., DA task) and one or both are bound to suffer.
Both are bound to end up disappointed, because the "real Vienna" they're looking for doesn't actually exist.
Both are bound to the Zn2+ ion in the bottom of the pocket in a bidentate fashion.
Our model does not propose that RFC and PCNA remain engaged at the P/T junction while both are bound to a given DNA.
Similar(53)
Both were bound to Bell Labs, Dr. Schawlow as an employee and Dr. Townes as a consultant.
In this two-headed bound state where both heads are bound to ADP, intramolecular tension is generated.
Stochastic simulations of the kinesin-1 and kinesin-2 hydrolysis cycles suggest that "front-head gating," in which rearward tension prevents ATP binding to the front head when both heads are bound to the microtubule, is diminished in kinesin-2.
The internal political dynamics in both countries are bound to shift as a result of Obama's reelection.
Cryptochrome proteins are phosphorylated by CKI only when both proteins are bound to mammalian Period proteins [ 12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com