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Both agents were used to avoid iodine absorption which could be problematic in premature infants.
Both agents were used at doses reported to show an inhibitory effect on mammary carcinogenesis [ 6, 7].
However, it was worth noting that when both agents were used in combination, at 2 h exposure ~22% more inhibition was observed.
U937 cells, which are sensitive to both agents, were used to illustrate that the flow cytometric method gives rise to a similar pattern of increased γH2AX as determination of foci by immunofluorescence.
Both docetaxel and ispinesib can induce mitotic arrest and apoptotic cell death; however, in the MX-1 tumour mouse xenograft model, preclinical data demonstrated synergy when both agents were used concurrently (data on file at GlaxoSmithKline).
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It is usually required to space administration times when both agents are used together.
Both agents are used for intravitreal injections, which is cumbersome for patients and is not suitable for preventive treatment.
These findings imply that in the Chinese health care setting, docetaxel is less costly per LY gained than is nab-paclitaxel, when both agents are used as alternatives to standard branded paclitaxel.
Since a synergistic effect was expected, both the agents were used in the concentrations of a low inhibitory effect on proliferation of Panc-1 cells.
The concentration producing the same or higher antibacterial effect (size of zone of inhibition) was reduced to half when both the agents were used in combination with respect to the concentrations required when used separately.
The actual agents used in the different trials varied – both IV and oral agents were used.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com