Sentence examples for both affinity and specificity from inspiring English sources

Moreover, by comparing the binding characteristics of the two proteins at varying salt concentrations, we show that the ionic strength makes significant and variable contributions to both affinity and specificity.

A particularity of carbohydrate protein recognition of lectins is that both affinity and specificity are achieved due to polyvalent interaction, whereas affinity of single ligand to lectin can be very low or not registered at all.

Due to the distinct nature of binding affinity and specificity [44], [45], achieving significant gains in affinity as well as target specificity may be possible by simultaneously screening point-variants for both affinity and specificity enhancement before combining them into an optimized variant.

We note that the DNA-protein contacts do not entirely follow the principle of recognition-code stereochemistry [43], [44], even though they have survived a selection pressure for both affinity and specificity, by adding competitor DNA to the phage binding mixture (43).

While individual reader PTM interactions are generally weak (micromolar KD), many remodelers possess multiple reader domains, suggestive of multivalent interactions that would increase both affinity and specificity.

Inspired by this mechanism, we have recently explored the thermodynamics by which a DNA clamp-like molecular receptor that recognizes a specific complementary oligonucleotide target through both Watson Crick and triplex-forming Hoogsteen interactions can improve both the affinity and specificity of recognition.

The goal of designed PPIs is to achieve both high affinity and specificity for the target protein.

Consequently, a number of putative domain binders with both high affinity and specificity were identified, from which the Src SH3 domain was selected as a case study and tested for its binding activity towards the sacum peptides.

Thus, for proteins with multiple conformations that are close in energy, such as many intrinsically disordered proteins, residues distant from the active site can alter both binding affinity and specificity.

Overall, we observed that the K0.5s of sugars for E457Q-hSGLT3 resembled those of hSGLT1 more than hSGLT3, along with changes in specificity, namely an increased selectivity against imino sugars and for 3DO-glc, indicating the remarkable role of amino acid 457 in determining both binding affinity and specificity in SGLT proteins.

This would enhance both the affinity and specificity of the extended primer.