Sentence examples for both affinity and potency from inspiring English sources
While alkyl and benzyl substitution provided affinities and antagonist potencies comparable to those of 4-PIOL, diphenylalkyl and naphthylalkyl substitution resulted in marked increase in both affinity and potency.
Our demonstration that removal of the 1-phosphate from IP3 reduces both affinity and potency significantly more than does removal of the 2′-phosphate from AdA is inconsistent with the notion that the high affinity of AdA results from its 2′-phosphate providing a supra-optimal mimic of the 1-phosphate of IP3 (Takahashi et al., 1994c).
The planar ligand DPN is both ERβ affinity and potency selective (Meyers et al., 2001).
The small hydrophilic group (hydroxymethyl) highly reduced the agonist affinity and potency thereby increasing subtype selectivity.
Among the structures evaluated, the highest affinity and potency in all series were exhibited by compounds containing 4-hydroxy and/or 2-chloro or 2-fluoro substituents.
However, no correlation between affinity and potency appears to exist when different toxin domains are combined with the same scFv antibody domain.
Two training sets containing either 127 or 69 compounds were used to generate QSAR models for in vitro binding affinity and potency, respectively.
X-ray crystallographic data of the lead molecule with p38 were used to design analogues with improved binding affinity and potency in a cell assay of LPS-induced TNFα production.
The final QSAR models as well as the information gathered from 3D contour maps should be useful for the design of novel ERα modulators having improved affinity and potency.
Point mutations for hD1R revealed that the loss in dopamine affinity and potency was attributed to Thr59, while the enhanced Emax of adenylyl cyclase was directly influenced by Ser65.
Firstly, the relationship between affinity and potency was examined in a panel of four scFv immunotoxins generated from different anti-CD3 monoclonal antibodies fused to the 38 kDa fragment of Pseudomonas aeruginosa exotoxin A (PE38).
