Sentence examples for both affinity and efficacy from inspiring English sources

At mGlu7 and mGlu8, VU0422288 positively modulated both affinity and efficacy of all three orthosteric agonists.

The biological activity of an agonist is a product of both affinity and efficacy.

SKF82958 has a chlorine atom in the meta position of the aromatic ring which has been shown to enhance both affinity and efficacy.

VU0155094 exhibited neutral efficacy cooperativity with L-AP4 and LSP-2022 at mGlu7, whereas both affinity and efficacy modulation contributed to changes in the glutamate response and the greater degree of overall cooperativity observed.

Novel molecular determinants have been found that enhance and impair both the affinity and efficacy of the receptor.

As with the co-expression of CLR-M42A/RAMP1-WT, the CLR-WT/RAMP1-W74K combination resulted in normal CGRP affinity and efficacy but displayed reduced affinity for both BIBN4096BS (316-fold, Fig. 2B) and MK-0974 (282-fold, Fig. 2E).

It should be noted that ideally, to make the above conclusion, the analysis should involve the in vitro and in vivo data from a series of EPOR agonists, including both partial and full agonists, with a range of receptor binding affinity and efficacy.

In vitro binding affinity and efficacy analysis demonstrated that the bivalent isoform had the highest binding affinity and in vitro efficacy.

Wafford, K.A., Whiting, P.J. & Kemp, J.A. Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.

This chapter discusses the practical aspects of pharmacological experimentation designed to measure drug affinity and efficacy.

Cytisine and varenicline have a similar affinity and efficacy for the nAChRs (α4β2*, α6β2*) that mediate the rewarding effects of nicotine (Papke et al, 2010; Grady et al, 2010; Picciotto and Kenny, 2013).