Sentence examples for both affinity and avidity from inspiring English sources

Regulation of LFA-1 through both affinity and avidity modulation is important for appropriate integrin activation in T cells (reviewed in [3]).

When the 'inside-out' signal is induced by interaction of specific receptors with their ligands, e.g., interaction of T cell receptor (TCR) with cognate peptide/MHC complexes (pMHCs), both affinity and avidity of LFA-1 for its ligand, intercellular adhesion molecule-1 (ICAM-1), are enhanced by its conformational change and spatial rearrangement.

From the analysis, we calculated an apparent equilibrium dissociation constant, K D,apparent, which captures both affinity and avidity.

The effectiveness of the antibody response is modulated by both the affinity and avidity of the antibody/antigen interaction.

Both receptor affinity and avidity may be differentially regulated in leukocyte endothelial cell interactions involving the β2-integrin (CD11a/CD18) [ 41, 42].

Conversely, as epithelia transition to malignancy they evade the microenvironmental constraints by both altering their integrin affinity and avidity for ECM proteins (inside-out signaling) and/or shifting their integrin expression [6], [8].

The durability of the antibody response and the importance of antibody isotype, affinity and avidity for vaccine effectiveness are discussed.

As the binding of a lectin to its glycan is a reversible interaction influenced by its binding affinity and avidity, we aimed to demonstrate that lectin-glycan-induced protocellular junctions can be reversed to mimic such temporary adhesiveness.

Our results demonstrate affinity and avidity of targeting moieties on nanoparticles as important design parameters to ensure specificity and avoid toxicities.

(2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers.

We found that affinity and avidity adjusted inserted (I) domain, the major binding site of LFA-1, on liposome surface enhanced the specificity toward lipopolysaccharides (LPS -treated or infLPS -treatedelial cells (HMEC-1) and morocytes (THP-1) vinflamed1 ovendothelialn, reflecells inherent affinity and avidity modulation of these molecules in physiology.