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Palonosetron is a 5-HT3 receptor antagonist that has demonstrated superiority in preventing both acute and delayed emesis when compared to older first generation 5-HT3 receptor antagonists.
The 'esterase profile' of a compound critically affects its possible application as pesticide or therapeutic agent as well as the ecotoxicity risks related to both acute and delayed toxicity in humans and warm-blooded animals.
18– 20 In contrast, palonosetron has demonstrated benefit in controlling both acute and delayed CINV.
The study evaluated the prevention of both acute and delayed emesis.
This central neurotoxicity may manifest as both acute and delayed complications.
46 The most recent trial conducted by Navari et al demonstrated high complete protection against both acute and delayed nausea.
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Current guidelines recommend the use of 5-HT3 receptor antagonist (RA) either alone or in combination with dexamethasone and/or a neurokinin-1 RA both in the acute and delayed phases.
Nausea severity was measured on a visual analog scale (VAS) from 0 to 10 according to subjective assessment during both the acute and delayed phases.
The median VAS was slightly greater for the granisetron regimen than the palonosetron regimen in both the acute and delayed phases, though this difference was not statistically significant (acute phase: 3.40 for palonosetron versus 3.58 for granisetron; delayed phase: 3.92 for palonosetron vs. 4.04 for granisetron; Fig. 8).
Two different pathways that lead to brain cell death are depicted in Figure 6, showing how calpain and caspase proteases may break down salmonid brain cellular proteins during both acute necrosis and delayed apoptosis phases of salmon head injury, respectively.
In the study which compared the olanzapine with aprepitant in patients using regimen containing cisplatin or AC therapy (doxorubicin, cyclophosphamide), complete control rates were almost the same in both acute phase and delayed phase.
More suggestions(15)
both rapid and delayed
both advanced and delayed
both instantaneous and delayed
both live and delayed
both standard and delayed
both confirmed and delayed
both direct and delayed
both dysfunctional and delayed
both constant and delayed
both axonal and delayed
both primary and delayed
both acute and long
both acute and subchronic
both acute and convalescent
both acute and longitudinal
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