Sentence examples for both activity and specificity from inspiring English sources

This transformation levels off the catalytic efficiency specific for each peptide, while maintaining differences in both activity and specificity of the different proteins.

As DNMT3L binding to DNMT3B also highly increases the activity of the methyl-transferase, the impaired interaction reduces both, activity and specificity of the enzyme, with effects visible in the ICF patient's DNA methylome.

We employed computational RNA structure design to improve both on-target activity and specificity of tsRNA in a herpes simplex virus thymidine kinase/ganciclovir suicide gene therapy approach targeting alpha fetoprotein (AFP), a marker of hepatocellular carcinoma (HCC) or human papillomavirus type 16 (HPV-16) pre-mRNA.

We reason that a coordinated, not independent, action of both conserved and non-conserved residues determine enzymatic activity and specificity.

We found that both aging and gender significantly affect γ-secretase activity and specificity; male mice exhibited a sharp decline in brain APP γ-secretase activity with aging whereas female mice did not.

When an effect is detected, the compound is modified in different ways to optimize its activity and specificity.

ELISA and Western blot studies have confirmed the bifunctional activity and specificity.

Therefore, the compound exhibited better therapeutic activity and specificity compared with the positive control 5-fluorouracil.

To enhance the activity and specificity of the human insulin promoter, we engineered a synthetic human insulin super-promoter (SHIP).

In this paper we present an HPLC method developed for quick activity and specificity analysis of serine proteinases.

This was used with a functional assay for protein disruption to perform high-throughput analysis of crRNA activity and specificity.