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Our data suggest that the SPAK CCT domain regulates BP by promoting SPAK activation by WNK isoforms that in turn enhance both activity and expression of the renal sodium co-transporters NCC and NKCC2 with potential concomitant effects on NKCC1 in the vasculature.
We have shown the increment in both activity and expression of such enzymes as glucose-6-phosphate dehydrogenase, NADP-dependent ICDH and malic enzyme (ME) in P. fluorescens subjected to Al toxicity [45].
Both activity and expression reduction of catalase are prevented by rosiglitazone.
The role of AMPK in regulating lipogenesis by reducing both activity and expression of SREBP1c is well established [ 32, 33].
Both activity and expression of root PM H+-ATPase were higher in the Al-tolerant than in the Al-sensitive cultivar.
Both activity and expression of these transcription factors (TFs) are repressed in normal somatic cells and hence their re-activation is instrumental for the re-programming of somatic cells into the iPSCs.
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Additionally, both the activity and expression of PEA3 factors can be regulated by receptor tyrosine kinases through MAP kinase signaling [17], [18].
These results indicate that 4-HPR inhibits both the enzymatic activity and expression of aromatase.
Several oncogenes and constitutively active growth factor receptors are known to upregulate both Nox activity and expression, including Ras, Flt3 and BCR-ABL, by mechanisms described in the previous section.
Thus, suppression of both enzyme activity and expression of ALDH1As led to the inhibition of HSC activation, which agrees with the recent paper that suppression of alcohol dehydrogenase (ADH) 3 inhibits HSC activation (Yi et al, 2014).
Downregulation of both Stat3 activity and expression of Stat 3-controlled pro-survival proteins, contributes to the induction of apoptosis in avicin treated tumor cells.
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both phagocytosis and expression
both activity and attention
both activity and coreness
both therapy and expression
both recognition and expression
both activity and transcript
both activity and residence
both number and expression
both activity and toxicity
both activity and symptom
both thought and expression
both feeling and expression
both activity and anticipation
both activity and enantioselectivity
both activity and similarity
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