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The PNPLA3 mutant form has a comparable reduction in both activity and affinity for triglycerides and retinyl palmitate (30).
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The effects on both basal activity and affinity for SecYEG were reversed on release of the clamp by DTT.
Further study showed that the biochemical functions of MCM, including ATP hydrolysis, helicase activity and affinity for DNA substrates, are increased markedly upon association with both Cdc45 and GINS (Ilves et al. 2010).
In the 1970s, the few studies performed with ScASNase1 demonstrated low activity and affinity to L-Asn14,17 L-Asn14,17
The apparent Michaelis Menten constant (KMapp) of the biosensor is calculated to be 1.7 mM, suggesting high enzymatic activity and affinity toward glucose.
In these cases, the metabolites exhibit pharmacological activity and affinity to the target receptors of the pharmaceutical.
PHMB is routinely used in textile industry due to its antimicrobial activity and affinity to the cellulose fabrics.
Cyanoguanidines have been investigated at length due to their strong pharmacological activity and affinity for P2X7 across a number of analogues.
The C2a Lys1014Asn mutation (analogous to the βGC Met537Asn mutation) increased activity and affinity between the two subunits in the absence of forskolin or Gsα.
Skeletal muscles of mice with muscular dystrophy have testosterone receptors with the same characteristics of activity and affinity as those of normal mice.
Besides, experimental evidences showed that the Val variant may have either lower or higher specific activity and affinity depending on the substrate [ 48].
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