When given orally, dolasetron plasma concentration is in most cases undetectable and its pharmacological activity is negligible, although after intravenous injection both active moieties are present at the site of action and trigger potential cardiac effects.
Recent work on a number of hybrid compounds, in which known antitumor compounds or simple active moieties of known antitumor agents have been tethered to distamycin frame or hairpin polyamides derived from distamycin, is reviewed.
In particular, PIN domains comprise the active moieties of the RNases that target mRNAs with stop codons in the eukaryotic nonsense-mediate decay system [ 35, 36].
It is generally believed that the myriads of eukaryotic spliceosomal introns, as well as the snRNAs that comprise the active moieties of the eukaryotic spliceosomes, have evolved from Group II introns [ 68, 69], leaving, perhaps, the most conspicuous imprint of the RNA World on modern genomes [ 70].
We implemented the active moiety of antipsychotics, taking into account the activity of metabolites.
Objectives: To determine the serum status in folate, pyridoxal-5′-phosphate (the active moiety of pyridoxine), cobalamin, and total homocysteine of chronic dialysis patients not routinely supplemented with B-complex vitamins and to evaluate induced intradialytic losses during high-efficiency hemodialysis.
ARS is a sesquiterpene lactone containing an endoperoxide bridge representing the active moiety of the molecule.
The active moiety of artemisinin-like drugs is an endoperoxide bridge, whose reductive homolysis is promoted by iron II -heme leadiron II -hemetered aleadingng radicals [10].
Findings: Our experiments show that the active moiety of oseltamivir is not removed in normal sewage water treatments and is not degraded substantially by UV light radiation, and that the active substance is released in waste water leaving the plant.
Because of a decrease in inflammation in the 5-ASA group, the authors concluded, that in the therapy of ulcerative colitis the active moiety of sulfasalazine was 5-ASA.
