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The survival of animal tissues and organs is controlled through both activation and suppression of programmed cell death.
As zooids represent a transient, mass-produced commodity during Botryllus asexual development, PCD regulation in this animal via both activation and suppression enables it to remove and recycle its constituent zooids earlier when intra-colony resources are low, while maintaining the functional filter-feeding state when resources are adequate.
ncRNAs have been recently found in surprising abundance, with novel classes and unexpected roles mediating evolution, organising chromosomal domains, chromatin remodelling and transcriptional regulation (both activation and suppression) [17], [18].
PCA3 is a putative ncRNA and ncRNAs are known to play important roles in transcriptional regulation (both activation and suppression), gene silencing, RNA splicing, and DNA imprinting and demethylation [17].
A complete theory of peripheral tolerance, however, must account for both activation and suppression signals and must additionally delineate how these two opposing signals are integrated for the eventual task of discriminating between dangerous pathogens and innocuous self and environmental materials.
Cytokines play a key role in both activation and suppression of T-cell proliferation.
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ASXL1 plays critical roles both in activation and suppression of Hox genes in axial patterning through regulating the polycomb group and trithorax group proteins.
Corticosteroids comprise the backbone of asthma therapy and act to reduce inflammation through both gene activation and suppression 43.
Furthermore, there are data to support the view that chronic stress appears to result in suppression of the immune response, whereas both immune activation and suppression have been associated with acute stress.
These findings delineate, at least in part, the underlying mechanisms by which Jhdm1b/vitamin C can enhance the reprogramming process and represent the contribution of the H3K36 histone modification in both gene activation and suppression during efficient pluripotent reprogramming [ 87].
Arousal and sleep (REM and NREM) are active and complex neurophysiologic processes, involving both neural pathway activation and suppression.
More suggestions(15)
both attaining and suppression
both generation and suppression
both silencing and suppression
both activation and learning
both ovulation and suppression
both overexpression and suppression
both activation and detoxication
both activation and chromatin
both activation and silencing
both stimulation and suppression
both activation and apoptosis
both activation and expression
both activation and valence
both promotion and suppression
both activation and surface
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