Differences between the toxicity of benzene and the halobenzenes are related to fundamental differences in their electronic structures and to the consequent pathways of metabolic activation and detoxication.
For chemicals that are metabolized in the nasal mucosa, the balance between metabolic activation and detoxication within a cell type may be a key factor in determining whether that cell type will be a target for toxicity.
Because levels of aromatic hydrocarbons (AHs) in urban sediments are correlated with prevalences of liver neoplasms in English sole, we have initiated detailed studies to evaluate the effects of endogenous and exogenous factors on uptake, activation and detoxication of carcinogenic AHs, such as benzo[a]pyrene (BaP), using spectroscopic, chromatographic, and radiometric techniques.
SRC2 knockdown both reduced TNF-α-dependent activation and abolished dexamethasone-dependent suppression of IL6, demonstrating that it has roles in both activation and suppression at this locus.
Understanding the extent of metabolism, both bioactivation and detoxication (conjugation by SULTs, UGTs, and GSTs), following exposure to environmentally relevant doses would greatly add to the impact of Bio-AMS studies such as this one.
Thus mutants which impact the movement of DIIIS4 may affect both channel activation and fast inactivation.
Both the cofilin activation and occludin decrease contributed to the TJ opening by capsaicin.
The consequence of metabolism, activation or detoxication, is a function of the nature of the substrate and of the characteristics and concentrations of the enzymes involved.
These associations are likely to be due to altered activation or detoxication of chemicals initiating these diseases, including components of tobacco smoke and neurotoxins.
