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Aside from the aforementioned type U compounds, the triterpenediol (TPD) compounds 3α, 24-dihydroxyurs-12-ene (8) and 3α, 24-dihydroxyolean-12-ene (21), which belong to the type O class, are both able to induce up-regulation of the cell death receptor 4 (DR 4) and TNF-α1, and thereby promote caspase-8 activation and produce oxidative stress in cancer cells [36].
CDDO-Im and sulforaphane were both able to induce Nrf2 nuclear translocation in gp91phox−/ and p47phox−/− macrophages, whereas zymosan failed to increase Nrf2 translocation above vehicle control (Figure 6D).
mMCP-6 and mMCP-7 were both able to induce tube formation in SVEC4-10 endothelial cells.
Our experiments demonstrate that LiCl and alsterpaullone, two widely used inhibitors of GSK-3 activity, are both able to induce apoptosis of tumour cells.
The two sequences were both able to induce a strong reduction in CR1 RNA levels, although at a different extent, in spheroids (Pt1) as well as in NTERA2 teratocarcinoma cells.
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Additionally, we confirmed that 15d-PGJ2 and CDDO both were able to induce PPAR-γ-dependent transcription as measured by their ability to induce PPRE-luciferase (PPAR-γ Response Elements-luciferase) (Fig 2C and [27]).
Although both are able to induce antiproliferative responses in many cell types, IFN- λ1 appears to be more limited.
This indicated that p38 kinase and Jnk1 or Jnk2 or both are able to induce the phosphorylation of B-Myb after UV irradiation.
We first showed that 5-Azacytidine, TSA and combination of both were able to induce luciferase activity under the control of RhoB promoter by a factor of respectively 2, 10.6 and 17.9 in BEAS-2B and of 2.4, 23.8 and 41.5 in A549.
Strains of both symbiovars are able to induce nodules on both G. orientalis and G. officinalis, but effective nodules are only formed on G. orientalis by sv.
Both compounds were able to induce apoptosis and cell cycle arrest at G0/G1 phase and upregulated p53 steady-state levels, while decreasing its main inhibitor MDM2, in HCT-116 cells.
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