Sentence examples for both a substrate for from inspiring English sources
Because the full-length Darpp-32 is both a substrate for phosphorylation by PKA (at Thr-34) and a feedback negative regulator of PKA, it is interesting to speculate that t-Darpp might function by antagonizing Darpp-32's feedback inhibition of PKA, thereby potentiating PKA signaling.
Mitomycin C (MMC) is both a substrate for and a mechanistic inhibitor of the NQO2 homologue NQO1.
Malonyl-CoA regulates the balance between lipogenesis and β-oxidation as it is both a substrate for fatty acid synthase (FASN) and an inhibitor of carnitine palmitoyltransferase I (CPT-1), which mediates uptake of fatty acids into the mitochondria.
Based on the percentages of the study population in the high- and low-clearance groups, it is hypothesized that, like mifepristone, telapristone is both a substrate for CYP3A4 and CYP3A5.
Recent work indicates that SV40 large T antigen can serve as both a substrate for the ATM kinase as well as its direct upstream activator through binding the Nbs1 component of the ATM-activating Mre11/Rad50/Nbs1 complex (Wu et al, 2004; Boichuk et al, 2010).
GSH has an important role both as a substrate for glutathione peroxidase (GPx), glutathione reductase (GR) and cofactor for GST [36, 37].
GaAs(0 0 1) has been one of the most intensively studied surfaces for the past 30 years due both to its importance as a substrate for epitaxial growth and to the challenge its phase diagram of complex structures presents to computational methods.
In short, just as we report here for pEndos and PP2A-B55, they concluded that pInhibitor-1 acts both as an inhibitor and a substrate for PP1.
Studies have also found that PHB is a substrate for Akt both in vitro and in vivo [ 30, 40, 117, 118].
It both activates and is a substrate for Aurora-A kinase and is important in mitotic spindle formation and chromosome segregation during cell division [reviewed in 22].
In addition, both metabolites act as a substrate for the regeneration of other essential antioxidants, which neutralize and regulate reactive oxygen species (ROS).
