We believe that CRM is a good alternative to the standard method from both a statistical and a practical point of view but further methodological research is necessary to address the issues related to the composite nature of the endpoint.
This shows an effect that is significant both in a statistical and a practical sense.
Circulating levels of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) are quantitative traits commonly measured in clinical practice and strongly associated with vascular disease, making them appealing traits to investigate from a statistical, clinical, and practical standpoint [3].
Yet, the decision to prematurely stop a blinded, randomized controlled clinical trial can be extremely complicated, involving a tangle of ethical, statistical, and practical issues.
Table 1 lists a range of theoretical, statistical and practical rationale for pooling individual participant data, which arose from our own observations, as well as from existing discussion in the literature (e.g., [ 1, 18, 20]).
Kotrlik and Williams (2003) highlight a particularly clear example in which statistical and practical significance differ.
Although the NGS data hold several extended promises, there are several outstanding statistical and practical considerations for performing a pathway-based (or a set-based) analysis of such huge data.
This paper addresses the statistical and practical characteristics of overall scores as an alternative to a global rating in summarizing patient survey results.
There are, however, important ethical, statistical, and practical issues in considering such a design.
From purely statistical and practical points of view, the SPADI appears as a more attractive outcome measure than shoulder ROM in this study.
In areas with very high prevalence of HPV, the practice of identifying risk factors can be troublesome from statistical and practical perspectives.
