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They reported an association between improvement in ODI score and both a single marker (rs4633) and a COMT haplotype [ 28].
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However, NMP22 had a relatively low specificity in our study both as a single marker and in combination with other markers.
The prognostic significance of RB-pathway deregulation is significant in multivariate models, and is true both as a single marker and in combination with other determinants of DCIS biology, including Her2 levels, Cox2 levels, and PTEN levels [ 49- 52].
This is in contrast to other studies reporting specificities of over 70% for both NMP22 as a single marker and in combination with cytology [ 5, 23].
Basically, the algorithm searches for areas with high contrast in both images that could originate from a single marker.
Association of these SNP's with both CD and UC, either as a single marker or combined has been extensively studied.
A potential limitation of this study is the retrospective nature of the collection of both cohorts; a prognostic trial of a single marker such as this can rarely be prospectively designed outside the setting of a clinical trial.
Unfortunately, the properties of molecular markers required to address both local and global levels of bacterial diversity are unlikely to be met by a single marker [51].
Moreover, in many cases, scientists are trying to find not a single marker but several that could be used together to get a more accurate reading.
a Single marker analysis.
Our aim was to use as few markers as possible, ultimately a single marker seen from quite a distance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com