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By integrating survival data from 198 treated AML patients with gene expression data for genes encoding proteins involved in the regulation of DNA replication, David et al. identified the CHEK1 gene and its product, the DNA replication checkpoint kinase CHK1, as both a prognostic indicator of survival and a therapeutic target to overcome resistance to the current standard of chemotherapy.
The clinical validity of Onco type DX® as both a prognostic indicator and a test predictive of likely chemotherapy benefit is supported by an evidence base of consistent results from multiple studies [ 6, 9, 10, 54, 55].
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ER status of breast cancer is important clinically, and is used both as a prognostic indicator and treatment predictor.
ER status is important clinically, and is used both as a prognostic indicator and treatment predictor since it determines if a patient may benefit from anti-estrogen therapy.
Our findings underscore the importance of the APACHE II score as a prognostic indicator in both ICU patients and non-ICU patients with invasive Candida infections.
Tumor vascular density may provide a prognostic indicator of metastatic potential or survival.
Naruse, K. et al. Lactate dehydrogenase is a prognostic indicator for prostate cancer patients with bone metastasis.
Compliance as a prognostic indicator: retrospective study of 505 patients treated and maintained for 15 years.
An elevated NLR has been shown to be a prognostic indicator in primary colorectal malignancy.
Eventually, miRNAs can provide new therapeutic strategies and can be used as a prognostic indicator.
Gu, J. et al. SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer.
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