Sentence examples for both a nuclear localization from inspiring English sources

Unlike SK1 which is localized in the cytoplasm, SK2 contains both a nuclear localization signal (NLS) and a nuclear export signal (NES), as a result its localization can vary in a cell-type dependent manner.

Considering that Pias proteins bear both a nuclear localization sequence and a nuclear export sequence [15], we speculated that the import of Trim32 into the nuclear dots might be mediated by the dynamic nucleocytosolic shuttling of Pias3.

FOXO proteins have both a nuclear localization sequence and a nuclear export sequence within the C-terminal DNA binding domain.

32 In this cassette the fluorescent reporter TagRFP is fused to both a nuclear localization sequence (NLS) and the transmembrane domain of the mitochondrially tethered adapter protein IPS-1.

When a GFP control protein containing both a nuclear localization signal (NLS) and an NES was expressed, the fusion-protein was detected in the whole cell (Taura et al., 1998).

Although the exact function of cytoplasmic WT1 remains to be elucidated, WT1 can shuttle between the nucleus and cytoplasm as it contains both a nuclear localization signal and a nuclear export signal [ 49].

Since both proteins have a nuclear localization sequence, it is just as likely that either partner could be responsible for nuclear transit.

Both spastin isoforms contain a nuclear localization signal, however, the long 68-kDa spastin isoform also bears a nuclear export signal and is efficiently exported to the cytoplasm in an exportin-dependent fashion.

Both mutp53 and MDM2 proteins contain a nuclear localization signal (NLS) and are mainly localized in the nucleus, where MDM2 binds to and ubiquitinates mutp53 protein.

Data obtained from immunocytochemical analysis showed that in both cell lines HMGB1 had a nuclear localization in controls and in cells exposed to doses of 2 and 4 Gy (Tables 3 and 4, Figure 6).

We also obtained a nuclear localization of both V5-ARID4B inoforms in all cell lines we tested, including primary cells as well as breast and cervical cancer cell lines (result not shown).