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Finally, necroptosis is accompanied by the release of high-mobility group box 1 protein (HMGB1, mean PONDR FIT score of 0.774), which is both a nuclear factor (which serves as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets) and a secreted protein serving as a potent mediator of inflammation.
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This suggested that, similarly to IL-1α and chromatin-associated cytokine HMGB1, IL-33 may act as both a cytokine and a nuclear factor.
IL33 is a dual-function protein that acts as both a cytokine and a nuclear factor.
In a similar manner to HMGB1, IL-33 can act as both a cytokine and a nuclear factor and has been linked to fibrosis through the actions of leukocyte recruitment and modulation of ECM genes [ 143, 144].
We have identified a nuclear factor that binds to double-stranded DNA ends, independently of the structure of the ends.
Estrogen-regulated MIF transcription in vitro via a nuclear factor κB-dependent mechanism.
NFAT, as a nuclear factor of activated T cells, is regulated by the calcium pathway.
Peroxide-mediated chromatin remodelling of a nuclear factor kappa B site in the mouse inducible nitric oxide synthase promoter.
A nuclear factor 1 probe was used as a control (5'-TTTTGGATTGAAGCCAATATGATA-3').
PPARγ is a nuclear factor required for gene transcription of many lipid synthesis enzymes.
In these cases, a nuclear factor alleviates an organellar problem arising due to a genomic mutation.
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