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This may be a consequence of either, or both, a higher baseline of the level of inbreeding or increased impact of purging in small populations; unfortunately the available data did not allow distinguishing between these potential explanations.
Those people prescribed insulin had both a higher baseline HbA1c and a greater mean reduction in HbA1c compared with the GLP-1 receptor agonist cohort.
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Decline in lung function was associated with an increase in BMI and smoking in both men and women, while a higher baseline BMI was associated with a greater decline in FVC but not in FEV1.
Prespecified subgroup analysis suggested a possible interaction according to lipid subgroup, with a possible benefit for patients with both a high baseline triglyceride level and a low baseline level of high-density lipoprotein cholesterol (P = 0.057 for interaction).
However, in a pre-specified analysis, a benefit regarding the primary outcome rate (first occurrence of nonfatal myocardial infarction, nonfatal stroke, or death from CVD causes) for patients with both a high baseline TG level (≥204 mg/dl) and a low HDL-C baseline level (≤34 mg/dl) was recognized for those on the simvastatin + fenofibrate combination [ 89].
Since both Fe(II) and H2O2 will absorb UV light, their absorbance curves have a higher baseline compared to a solution with only adenine.
A higher baseline ACR predicted a faster decline in eGFR for both sexes.
Subjects with a low baseline are, both mathematically and physiologically, susceptible to larger percentage improvements (~15 35%) than subjects with a higher baseline (~6%–13%) [ 21, 37].
They tend to be sicker patients facing a higher baseline risk of cardiovascular disease, Glaxo said.
Its 40% cut by 2030 is compared to a higher baseline of 1990.
Rising seas create a higher baseline for future storm surges.
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