Cisplatin-induced cast formation, tubular dilation and brush border loss were significantly alleviated by HQH pretreatment (Fig. 1D).
FA-induced (Fig. 6C) and IRI-induced (Fig. 6D) cast formation, tubular dilation and brush border loss were significantly alleviated with HQH and Dex pretreatment.
The tubule injuries include cast formation, tubular dilation and brush border loss, which was analyzed by the quantities of injury tubules in >10 random high-power fields (HPF).
In addition to the Proposal, the plan contemplates extension of the Directive on the tax treatment of mergers and measures dealing with cross-border loss relief, transfer pricing and double tax conventions.
Morphological changes in the sepsis group were scored 24 h after CLP injury based on brush border loss, tubular degeneration, and vacuolization in the proximal tubules.
Tubular damages were assessed on PAS-D stained 4 µm-thick sections by scoring tubular cell necrosis, tubular dilatation, cast deposition and brush border loss in 10 non-overlapping fields (×400 magnification) in the corticomedullary junction [7].
In line with the preserved renal function in TLR4−/− mice, kidneys from these animals showed significantly less renal tubular damage such as widespread tubular necrosis, tubular dilatation, brush border loss and cast formation in the outer medulla one day after I/R injury compared with wild type kidneys (figure 2).
The percentage of damaged tubules in the corticomedullary junction was estimated by a blinded pathologist using a 5-point scale according to the following criteria: tubular dilatation, cast deposition, brush border loss, and necrosis in 10 randomly chosen, non-overlapping fields (×400).
These features included brush border loss, nuclear condensation, cell swelling, a consistent loss of nuclei, and hemorrhage.
Sections from the IPC alone kidneys were comparable with controls, although some brush border loss and cellular vacuolation was seen.
