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However, a recent meta-analysis of clinical trial outcomes for the PPARγ agonist rosiglitazone found a significant increase in the risk of myocardial infarction, and a borderline significant risk of death from cardiovascular causes [4].
A borderline significant risk reduction of all-cause mortality was also shown compared with other OHA in monotherapy.
Being a theoretically interesting and borderline significant risk factor for death of all causes, we decided to include it in the further analyses.
In multivariate analysis, exposure to broad-spectrum antimicrobial drugs was a borderline significant risk factor (adjusted OR 2.24, 95% CI 1.00 5.02, p = 0.05).
For the BSID 111 motor subscale, we found that PVL (p = 0.008) was a significant factor and that duration on oxygen (p = 0.064) was a borderline significant risk factor for BSID 111 motor score.
Regarding the measures determined at 12 months, there is a trend towards increased risk for recurrent wheeze at 2 years, with the objective measure of UCot being associated with a borderline significant risk for recurrent wheeze (OR 2.2, [0.99, 4.7], p = 0.051).
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Results from a large cohort of US veterans showed that men with diabetes had a borderline significant reduced risk of stomach cancer (adjusted relative risk = 0.95, 95% CI, 0.89 1.02), and this association was more pronounced in black veterans (adjusted relative risk = 0.85, 95% CI, 0.75 0.96).
Results The risk of mental disorders in children born after in vitro fertilisation or intracytoplasmic sperm injection was low, and was no higher than in spontaneously conceived children, except for a borderline significant increased risk of tic disorders (hazard ratio 1.40, 95% confidence interval 1.01 to 1.95; absolute risk 0.3%).
The differential effect of these two htSNPs was present in the haplotype analysis as well: The risk haplotype among Hispanics included C-G at these two loci and was associated with a borderline significant increased risk, while among non-Hispanics the haplotype including C-G at these two loci showed no association.
This yielded a borderline significant increased risk of late AMD for persons homozygous for rs3793784 (OR 1.39, 95%CI 1.02 1.89).
In unadjusted analysis we found a borderline significant increased risk associated with ETS.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com