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A borderline significant interaction was observed for insulin use among participants with type 2 diabetes (−482CT*BMI p = 0.06, −455TC*BMI p = 0.02).
A borderline significant interaction was found between the CT genotype of the VEGF SNP and PIH on %FGV (p = 0.063) (compared to the CC genotype).
A borderline significant interaction was found between the TT genotype of the IGFR1 SNP and %FGV (compared to the GG genotype) (p = 0.07).
For OS a borderline significant interaction was demonstrated such that GD improved OS compared to D in patients with TIMP-1 negative tumors.
A borderline significant interaction was also observed for SULT1A1 and smoking (AP = 0.36; 95% CI: −0.021 0.747), with an OR of 3.05 (95 CI: 1.73 5.40) for those SULT1A1 variant allele carriers who were smokers (Table 4).
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No significant interaction was observed.
No significant interaction was observed for rs16856785.
Significant interaction terms were route (P=0.03) and calcium (P=0.04), and borderline significant interaction terms were bisphosphonate use (P=0.06) and interval (daily v non-daily, P=0.12).
There is a borderline significant interaction between the ApoE4 allele, and red meat intake with respect to MSI-H CRCs (P=0.06), whereas no significant interaction is detected between ApoE4 and red meat with respect to MSS CRCs (P=0.13).
Additionally, a borderline significant interaction for OS was observed between TIMP-1 status and benefit from GD compared to D (Pinteraction = 0.06) such that median OS increased by nine months for TIMP-1 negative patients receiving GD.
A borderline significant interaction (p = 0.05) was observed for one outcome: concordance between stated decision and action taken, where encounters with female clinician/male patient showed increased concordance in the decision aid arm compared to control (8% more concordant encounters).
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