There was borderline significant difference in genotype distributions of SNP +190G/C between CHD cases and controls, but adjustment for the conventional risk factors such as age, sex, pack-year of smoking, drinking, activity, hypertension, DM, and family history of CHD yielded significant results (P = 0.012).
The only (borderline) significant difference in the laboratory test results was for serum alkaline phosphatase at day 42 and day 0, attributable to a significant decrease at 42 days in the placebo group (p = 0.03).
There was a borderline significant difference in E2 level (p = 0.05) between those who had taken their last tablet on the day of blood sampling (n = 17) and those who had taken their last tablet the day before (n = 11).
There was a borderline significant difference in the disabilities of arm, shoulder and hand (DASH) at one time point (12 months) in favour of the locking plate, but this was well below the minimum clinically important difference.
There were no significant differences in baseline characteristics between groups (Table 1), except for a borderline significant difference in diabetes social support (PL 4.0 vs. CHW 4.4, P = 0.053).
When BMI z score over time was dichotomized as ≤0 or >0, there was a borderline significant difference in risk of islet autoimmunity between the two categories [χ(1) = 2.7, P = 0.09] (Table 2).
The χ tests for distribution showed no significant differences between cases and controls in most of the genotype frequencies except for borderline significant differences in CYP17 -34T>C (A1> A2) between cases and controls.
Unadjusted comparisons of cardiovascular risk factors revealed frankly significant or borderline significant differences in AI (t = 2.576, p = 0.011), PWV (t = -1.53, p = 0.128), and mean maximum IMT (t = -1.40, p = 0.165) between AMD progressors and non-progressors (Table 3).
No significant differences were found in weight and a borderline significant difference was found in BMI z-scores (-0.18 ± 1.19 vs. 0.27 ± 0.96 (p = 0.05)).
The unsupervised hierarchical clustering of these tumors results in two main branches; the distribution of metastases as first event between these two main branches shows a borderline significant difference; 3/28 (11%) patients in the left branch developed distant metastases versus 14/43 in the right branch (33%), P value = 0.047.
Consistent with our results, Salih et al.[12] found a borderline significant difference of rs6265 polymorphism in migraine patients, demonstrating a positive correlation between BDNF rs6265 polymorphism and migraine.
