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Therefore, before this test is implemented as a diagnostic tool for cases with borderline observations in neonatal screening, there is an urgent need to obtain and validate reference data for NPD measurements in infants and very young children with CF and in healthy controls of the same age.
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Cosmology is a borderline case: since observations of cosmological significance are so rare and hard-won—Hubble's observation of the red shift was one of the first solid ones it is very difficult, not to mention brave, to tie one's cosmological theory to Popper's falsificationist principle as a guarantee of scientific acceptability.
As a result, there may be an incentive for private hospitals to encourage the admission of borderline infants for observation in a special care unit.
As such, there may be an incentive for private hospitals to encourage paediatricians to admit borderline infants for observation, and thus some may be offered admission to a special care nursery unnecessarily.
The commonly used 'no-call' procedure for the observations of borderline quality should be modified.
The commonly used 'no-call' procedure does not always a best option for observations of borderline quality.
The first option is to discard the observations of borderline quality using the 'no-call' procedure which may lead to MCB.
When 'no-call' procedure is applied to those observations of borderline quality, we showed earlier that the biased estimation is dictated only by MAF and c.
As shown above, the commonly-used 'no-call' principal for the observations of borderline quality is not always the best choice.
Otherwise, it is better to call the observations of borderline quality at the cost of genotyping errors (grey area above the line in Fig. 4B, and Additional file 4B & 5B).
It was suggested that 'no-call' procedure should be taken where observations of borderline quality be removed from allele calls in order to keep the genotyping error rate as low as possible [ 29].
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