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We observed that only a borderline modification of the Ca/P ratio could be observed under SrRan treatment compared to the control group, and this observation is in agreement with the fact that Sr is essentially integrated into the hydrated layer and is rare in the hydroxyapatite crystal.
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Regarding the smoking influence, the fasting glucose (p = 0.021), both HOMA-IR (p = 0.003) and QUICKI (p = 0.006), SHBG levels (p < 0.001) and FAI (p = 0.003) improved significantly in non-smokers during the study and they showed no changes or only borderline modifications towards a better status in smoker PCOS subjects.
The borderline effect modification by wild-type GSTA1*A/*A genotype on associations between GSTM1-null and analyzed outcomes was found only for death from stroke.
Borderline effect modification on the association between tibia lead and uric acid was also observed in older participants (Table 3, panel 2, tibia lead models).
Basu et al. (2008) found borderline significant effect modification by ozone in two counties, but none in their combined analysis of nine counties in California, and they found no evidence of confounding by ozone.
Results are presented separately for men and women due to significant or borderline non-significant effect modification by sex.
By alcohol intake, blood cadmium levels were positively associated with eGFR levels, but effect modification was borderline statistically significant.
This apparent effect modification was statistically borderline significant (P for interaction = 0.05).
This BMI-methylation interaction reached borderline significance in formal tests for effect modification (p for interaction = 0.085).
A probable medication modification was defined as a borderline susceptible or resistant drug in the patient's regimen for which there was an alternative susceptible drug available, or for a borderline susceptible isolate, a dose increase was possible [ 4].
No significant effect modifications were detected, expect for a borderline significant interaction (P value = 0.08) indicating that the positive association between height and breast cancer may be limited to women with mixed/dense breasts (Table 4).
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