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Data from the MOSAIC [ 6] and the NSABP protocol C05-C08 trindicatedcated a borderline benefit of 2 3 % in 5-year OS rates when using additional oxaliplatin [ 15].
When studies at low risk of bias were examined by sepsis subgroup (sepsis, severe sepsis, septic shock), no statistically significant benefit was observed for each individual group (for septic shock, relative risk 0.91; 95% confidence interval 0.81 to 1.01; P=0.09), but overall borderline benefit was demonstrated (relative risk 0.92; 0.85 to 1.00; P=0.05) (online supplement).
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However, conservatively treated patients reported fewer arm problems and a borderline significant benefit in body image.
In the IPASS study, EGFR FISH positivity was associated with higher response rate and a borderline PFS benefit from gefitinib when compared with platinum-based chemotherapy (P=0.044; Fukuoka et al, 2009).
Rather surprisingly, studies suggest that even people who have borderline high cholesterol benefit from drugs that lower cholesterol.
Companies that change a borderline vehicle can benefit in two ways, because a big wagon that can sink an automaker's car average may improve its truck average.
Patients with low or borderline LVEF may benefit from a non-anthracycline-containing regimen.
This implies, as have other trials [ 4] that patients with borderline hypercholesterolaemia may benefit from treatment.
However, we decided to give these borderline associations the benefit of the doubt, and comment on them in our discussion.
A borderline trend towards benefit of albumin was observed after studies at high risk of bias for this bias domain were excluded (relative risk 0.93; 95% confidence interval 0.86 to 1.00; P=0.06).
A borderline significant survival benefit was seen with G17DT compared to placebo (median survival 150 vs 83 days; Wilcoxon P=0.047), although there was a lower incidence of metastatic stage IV disease in the G17DT arm (73 vs 84%, respectively) (Gilliam et al, 2004).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com