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All normal ovarian tissues, benign, borderline and grade 1 tumours showed PPAR β staining localised in the epithelium and stroma.
Neutrophil gelatinase-associated lipocalin expression was significantly upregulated in ovarian cancer tissues with borderline and grade I tumours showing the highest expression (Lim et al, 2007).
As compared with normal ovaries, the median values of HAS3 in borderline and grade 1+2 malignant tumors were not changed, while grade 3 showed a trend for decline (-44%) (Fig. 1C).
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Borderline changes and grade I or IIA T cell-mediated rejection were treated with 1.5 2 g of methylprednisolone.
The treatment needs of the patients were categorized as Grade 1 (no treatment need), Grade 2 (little treatment need), Grade 3 (borderline need), and Grade 4 and 5 (high treatment need).
Staining for β-catenin was mainly confined to the cell borders in benign adenomas, borderline and high grade tumours.
Ovarian serous tumours of borderline and low grade are thought to arise from a step-wise progression from adenoma to borderline tumour to carcinoma through the Ras-Raf signalling pathway (Bell, 2005).
Different tumourigenic pathways have been proposed in the development of borderline and low-grade serous carcinomas (Type I) versus high-grade serous carcinomas (Type II) [ 2].
We show that normal and benign ovaries lack overt JAK2 activation, which was only present in low- and high-grade ovarian carcinomas, despite JAK2 expression in normal ovaries, benign, borderline and histological grades of tumours.
These data suggest that surface epithelial neoplasms comprise a small but significant proportion of ovarian tumors in the pediatric population, and they exhibit a marked preponderance for benign, borderline, and low-grade malignant subgroups.
In some borderline and high-grade tumours, staining of the reactive stroma was also evident.
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