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The 200 estimates (one estimate for each bootstrap dataset) of the calibration slope are then averaged.
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The final model converged for 977 out of the 1000 bootstrap datasets (of those, covariance step was complete for 856 datasets).
One thousand non-stratified bootstrap datasets of garenoxacin were generated using plasma samples from the five studies (phase I−III studies).
Bootstrap datasets of 500 replicates for ML analysis and 200 replicates for the NJ analyses were created using SEQBOOT in PHYLIP and analyzed by the respective methods.
In lieu of using internal files, the potential exists to internalize the physical creation of the bootstrap dataset instead of relying on the external seqboot program.
The mean value of r2 and |D'| was calculated for each bootstrap dataset and the distribution of all means was used to estimate the confidence intervals.
The larger the number of wild bootstrap datasets, the more satisfactory the estimate of a statistic will be.
A bootstrap dataset has the same number of genes and conditions as the original data, but with some conditions occurring several time and some conditions not occurring at all (i.e. drawn with replacement).
A bootstrap dataset is an imitation of the original dataset and is constructed by the random sampling of patients "with replacement" (that is, a patient can be selected more than once) from the original dataset.
Methods were evaluated by fitting models with error function and absolute sigmoid protection curves to bootstrap datasets from the 27 combinations of protection curve and illustrative dataset for which maximum likelihood estimates (MLEs) had been found.
Our network was validated statistically by first inferring a number of networks from different bootstrap dataset, and then (a) assessing the agreement between these bootstrap networks and the original network (stability) and (b) using the regression models from the bootstrap networks to predict expression values in the hold-out sets (predictive power).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com