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They calculated Bootstrap confidence scores for 62876 interactions between 5195 proteins.
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All Bootstrap confidence scores are between 0 and 1.
All Bootstrap confidence scores are between 0 and 1 and the original network contains 62 876 interactions.
Confidence scores for each branch are bootstrap support values obtained from 500 independent resamplings of alignment positions.
The result is a matrix S where the final confidence score for is given by (18) To further improve inference and become more robust against over-fitting and sampling errors, we use a bootstrapping strategy.
The estimation of the bootstrap confidence interval for the LS score using B bootstraps will need O(Bn) calculations.
Because replicates are available for this dataset, we are able to obtain the bootstrap confidence intervals for the LS score and they are given in Table 4. Interestingly, we found most of the top LS associations involve high degree nodes, such as genes 48941(189), 29494(12950427993(128), 27993(116), 436287(106), 32607 58), and 51986 52) (degree in parenthesis).
With replicates, it is possible to evaluate the variation of and to give a bootstrap confidence interval for the local similarity (LS) score as defined in Ruan et al.[ 11].
The present study introduces interval matching using bootstrap confidence intervals for accommodating estimation errors of propensity scores.
Thus, we resort to bootstrap to give a bootstrap confidence interval (CI) for the LS score.
Fig. 6 95% bootstrap confidence intervals for global weights.
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