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* = bootstrap C-index.
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It was internally validated with bootstrapping (c-index = 0.75, chi-square = 1,220.8) and externally validated in patients with ischemic cardiomyopathy from the Sudden Cardiac Death Heart Failure Trial (SCD-HeFT) database (c-index = 0.64, chi-square = 14.1).
When MI and bootstrapping were combined at the range of 0% (full model) to 90% of variable selection, bootstrap corrected c-index values of 0.70 to 0.71 and slope values of 0.64 to 0.86 were found.
Prediction models were validated via the bootstrap and c-index measure.
By applying the bootstrap the c-index is adjusted to 0.69 and 0.70.
However, unclear is if they presented the bootstrap corrected c-index.
The bootstrap corrected c-index was 0.71 for all four methods.
The bootstrap corrected c-index for model predicting overall and cause-specific survival was 0.73 and 0.74, respectively.
When CA-125 was omitted from the multivariable model, the bootstrap-corrected C-index for the nomogram decreased to 0.631 (bootstrap-corrected, 0.626).
The bootstrap-corrected c-index for the model was 0.74.
The bootstrap-corrected C-index was 0.789, indicating acceptable discrimination.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com