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They turned this theory into reality by boosting the expression of the genes responsible and crucially showed this worked in agricultural fields, with a 15% increase in productivity.
These should be directed at the level of gene selection and delivery, in order to identify the optimal cytokine and achieve efficient and durable cytokine expression, and at the level of improving immune stimulation, i.e. by co-administration of co-stimulatory molecules including B7 and CD40, or boosting the expression of tumor antigens or MHC class I molecules.
Recently, Rose et al. have demonstrated that signals responsible for boosting the expression are most abundant in introns near the transcription start site and that the compositional difference between promoter proximal introns and distal introns can be used to predict the ability of an intron to stimulate expression [21].
Instead, selection may operate at functional level, for example, in boosting the expression of AMPs [ 13].
Thus, facilitating the release of Bim using BH3 mimetics or boosting the expression of Bim using BIRD-2 might present interesting avenues to enhance BDA-366-induced cell death.
The number of genes to be affected by O2 and O7 suggests that these, and in particular O2, represent an evolutionary ancient factor responsible for modeling intermediary metabolism, which has been subsequently recruited for boosting the expression of α-zeins storage products.
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Active NtrC binds to DNA and boosts the expression of certain genes that allow the cell to live without nitrogen.
We hypothesized that, after the first neonatal injection, the degeneration of muscle to fibrocalcific/fibroadipous tissue was prevented, thus a late injection with a different serotype could result in a transduction of the surviving muscle and boost the expression of the delta-sarcoglycan.
During 28-35 DAP maturation stages, seeds boosted the expression only 2 to 4-fold [ 5].
The incorporation of the hCMV enhancer element into the expression cassette further boosted the expression levels with both promoters.
A surprising effect of Y27632 was the phosphorylation of Stat3-ca, which boosted the expression of downstream genes.
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