In the absence of a pre-defined immunological correlate of protection, the key question when developing a new TB vaccine is whether such significantly enhanced immune responses seen after the MVA85A boost in both the short and long interval boosting studies are accompanied by an improvement in protective efficacy.
The average number of subjects per boosting study was 91 (range 9 to 530).
The Boost study is part of Centre for Intervention Research in Health Promotion and Disease Prevention, National Institute of Public Health, University of Southern Denmark, Øster Farimagsgade 5A, 1353 Copenhagen K, Denmark.
The Boost study is funded by a 5-year donation from TrygFonden including funding of each author and coverage of expenses related to intervention, implementation and evaluation.
The Boost study is a theory- and evidence-based multi-component intervention which combines environmental and educational strategies in schools, families and local communities to increase FV intake among 13-year-olds' (year 7) [ 31].
The Boost study was implemented for nine months in the school year of 2010/2011.
The Boost study was implemented at intervention schools for nine months during the school year 2010/2011.
Parents who did not want their children to participate in the evaluation of the Boost study were able to indicate this in the parental baseline questionnaire and in follow-up questionnaires (passive consent).
The aim of the Boost study was to increase FV consumption among 13-year-olds (school year 7) by improving access to FV at school, in families and local communities.
Natalie Gil was told she couldn't work part-time while at university, Alexa-Jane Moore says working alongside her studies is a boost to her employability.
A potential worry in all HSP-overexpression or -boosting studies is that it leads to network adaptations (which would annihilate long-term effectiveness) or to multiple side effects, including enhancement of carcinogenesis, as was demonstrated for the manipulation of HSF-1 activity (Mendillo et al., 2012).
