Implementation of MenC vaccine prime and boost schedules with MenC tetanus toxoid conjugates seems more likely to induce sustained protection against MenC disease in early childhood.
So convinced is the airline BMI of Sierra Leone's potential as a holiday destination that it will shortly take over the non-stop London-Freetown route from UK carrier Astraeus, boosting its schedule to four flights a week.
In mice, we demonstrate that microneedle-mediated delivery of ChAd63.ME-TRAP induced similar numbers of transgene-specific CD8+ T cells compared to intradermal (ID) administration with needle-and-syringe, following a single immunisation and after a ChAd63/MVA heterologous prime-boost schedule.
Prime-boost regimens comprising ALVAC-HIV (prime) and human immunodeficiency virus type 1 (HIV) Env (boost) induce HIV-specific neutralizing antibody and cell-mediated immune responses, but the impact of boost schedule and adjuvant requires further definition.A phase 1 trial was conducted.
HVTN 204 enrolled 480 volunteers and evaluated the DNA prime - rAd5 boost schedule only.
Awaiting better evidence, all CKD patients should receive pneumococcal vaccination, either in a PCV-13 prime PPV-23 boost schedule, or with only a prime PPV-23 vaccination.
One of the more probable scenarios leading to the optimal immunization strategy of next-generation vaccines would be a prime-boost schedule in which DNA or live carrier vaccination are followed by boosts with a polyvalent subunit vaccine.
In all, 19 patients with olfactory neuroblastoma (ONB) or neuroendocrinecarcinoma (NEC) were treated with two courses of cisplatin/etoposide chemotherapy, followed by high-dose proton photon radiotherapy to 69.2 CGE using 1.6 1.8 CGE per fraction twice daily in a concomitant boost schedule.
Recent clinical trial and post-introduction data suggest that two doses of human papillomavirus vaccine may be sufficient protection for girls aged 9-14 years when administered in a prime-boost schedule with at least six months between doses to allow affinity maturation of memory B cells elicited by the first dose.
Vaccinated mice in LASVpp alone and DNA prime + LASVpp boost schedules were protected against 100 AID50 of LASV pseudovirus challenge, and it was found that in vivo efficiencies correlated with their anti-LASV neutralizing activities and MCP-1 cytokine levels in serum sampled before infection.
